Possible Interaction: Amphetamine and N-Methyl-3,4-Methylenedioxyamphetamine

“Consequently, in vivo, MLA significantly prevents MDMA- and METH-induced neurotoxicity at dopaminergic level (mouse striatum), without affecting hyperthermia induced by these amphetamines.”

“Oxidative stress has been demonstrated to occur in response to high doses of substituted amphetamines such as methamphetamine (METH) and 3,4-methlyene-dioxymethamphetamine ( MDMA).”

“Alcohol, nicotine, amphetamine , and other drugs, can also affect the psychobiological pro.les of ecstasy polydrug users in complex ways.”

“Support for needle and syringe exchange programs (OR 8.5) and a heroin prescription trial (OR 8.1); approval of the … 11.2); support for the legalisation of the personal use of amphetamines (OR 5.2); and histories of having used amphetamines (OR 7.2), … for having used Ecstasy.”

“ MDMA produced increases in subjective effects indicative of both stimulant (increases in POMS Elation, ARCI Amphetamine , VAS High and Stimulated scale scores) and hallucinogenic effects (increases on five of the six scales of the Hallucinogenic Rating Scale).”

“Furthermore, the use of ecstasy in the Netherlands is often combined with the use of amphetamine.”

“In contrast, the reported use of amphetamine by regular users of ecstasy seems to be associated with a reduction in nigrostriatal DA neurones.”

“Results: Striatal [123I]β-CIT binding ratios were significantly lower in combined ecstasy and amphetamine users compared to sole ecstasy users (6.75 versus 8.46, respectively: –20.2%, P=0.007).”

“ MDMA significantly and dose‐dependently increased body temperature, a hallmark of amphetamines.”

“ MDMA enhanced DA-induced cellular responses but reduced those of amphetamine.”

“These findings raise the possibility that MDMA may have the potential to produce cardiovascular and/or cardiac toxicity similar to that elicited by other amphetamine analogs.”

“The synaptosomal incorporation and sequestration of [3H]MDA, [3H]methylenedioxymethamphetamine , and [3H]amphetamine described in the present report may be important in the molecular mechanism of action of monoamine release induced by the amphetamines.”