Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Amphetamine and Monoamine Oxidase Inhibitors

Research Papers that Mention the Interaction

However, coadministration of these substituted amphetamines with an MAO‐A inhibitor causes significant potentiation in the ability to increase extracellular levels of 5‐HT for MDMA, but not PMA.
Clinical and experimental pharmacology & physiology  •  2007  |  View Paper
The acetylenic monoamine oxidase inhibitors , pargyline and clorgyline, have been used to modulate the binding of spin labeled amphetamine.
Biochimica et biophysica acta  •  1983  |  View Paper
These monoamine oxidase inhibitors also interfered with the metabolism of 3 H-amphetamine, and significantly delayed the disappearance of amphetamine from the mouse brain.
European journal of pharmacology  •  1971  |  View Paper
The accumulation of 5-HT in brain was reduced when the animals were treated with N,N-dimethyltryptamine, α-ethyltryptamine, p-methoxy amphetamine or p-chloromethamphetamine after receiving a monoamine oxidase inhibitor.
Biochemical pharmacology  •  1971  |  View Paper
Nialamide, pargyline and tranylcypromine, three monoamine oxidase inhibiting drugs, and the microsomal enzyme inhibitor SKF 525‐A significantly decreased the amount of amphetamine removed from the portal circulation of the isolated perfused liver of the cat.
The enhancement of the vascular actions and toxicity of amphetamine by monoamine oxidase inhibitors could be explained in terms of these findings.
The Journal of pharmacy and pharmacology  •  1970  |  View Paper
The degree of potentiation of amphetamine toxicity by monoamine oxidase inhibitors varied from one to another, the range being from pargyline, which increased the toxicity of amphetamine about 3-fold, to mebanazine which increased it about 100-fold.
European journal of pharmacology  •  1969  |  View Paper
The anorectic effect of benzylamine and amphetamine in mice was potentiated by pretreatment with amine oxidase inhibitors.
InflammoPharmacology  •  2004  |  View Paper
At sufficiently high doses, the amphetamines resulting from the metabolism of some monoamine oxidase inhibitors , e.g. selegiline (deprenyl), may directly produce toxicity from the pharmacodynamic interaction with the parent antidepressant.
CNS drugs  •  1997  |  View Paper