Possible Interaction: Amphetamine and Monoamine Oxidase Inhibitors

“However, coadministration of these substituted amphetamines with an MAO‐A inhibitor causes significant potentiation in the ability to increase extracellular levels of 5‐HT for MDMA, but not PMA.”

“The acetylenic monoamine oxidase inhibitors , pargyline and clorgyline, have been used to modulate the binding of spin labeled amphetamine.”

“These monoamine oxidase inhibitors also interfered with the metabolism of 3 H-amphetamine, and significantly delayed the disappearance of amphetamine from the mouse brain.”

“The accumulation of 5-HT in brain was reduced when the animals were treated with N,N-dimethyltryptamine, α-ethyltryptamine, p-methoxy amphetamine or p-chloromethamphetamine after receiving a monoamine oxidase inhibitor.”

“Nialamide, pargyline and tranylcypromine, three monoamine oxidase inhibiting drugs, and the microsomal enzyme inhibitor SKF 525‐A significantly decreased the amount of amphetamine removed from the portal circulation of the isolated perfused liver of the cat.”

“The enhancement of the vascular actions and toxicity of amphetamine by monoamine oxidase inhibitors could be explained in terms of these findings.”

“The degree of potentiation of amphetamine toxicity by monoamine oxidase inhibitors varied from one to another, the range being from pargyline, which increased the toxicity of amphetamine about 3-fold, to mebanazine which increased it about 100-fold.”

“The anorectic effect of benzylamine and amphetamine in mice was potentiated by pretreatment with amine oxidase inhibitors.”

“At sufficiently high doses, the amphetamines resulting from the metabolism of some monoamine oxidase inhibitors , e.g. selegiline (deprenyl), may directly produce toxicity from the pharmacodynamic interaction with the parent antidepressant.”