Possible Interaction: Amphetamine and Metyrosine

“Three days after withdrawal, the renewed administration of α‐MT again caused a high degree of blockade of amphetamine‐induced euphoria.”

“After rats were trained to differentiate between the effects of d-amphetamine and saline in a state-dependent task, pretreatment with the tyrosine hydroxylase inhibitor, α-methyl-p-tyrosine , significantly decreased amphetamine discrimination.”

“Unilateral intrastriatal microinjections of α-methyl-p-tyrosine followed by systemic amphetamine treatment produced turning ipsilateral to the side of the injection in rats from 12 days of age to maturity, but not in rats younger than 12 days.”

“Pretreatment of the lesioned mice with either α-methyl-p-tyrosine or haloperidol abolished the circling response induced by amphetamine or scopolamine.”

“First, catecholomines are probably involved in drug-induced reward, because (a) amphetamine euphoria is inhibited by α-methyltyrosine , (b) self-stimulation in rats is inhibited by drugs blocking catecholamine synthesis, and (c) some of the most rewarding drugs of dependence (opioids, cocaine and amphetamine) interact with catecholamines.”

“Pretreatment of animals with α-methyltyrosine at a dose sufficient to prevent the locomotor stimulation and stereotypy promoted by amphetamine , or by haloperidol, failed to prevent the amphetamine-induced increase in 5HIAA, indicating that these serotonergic effects are not secondary to the amphetamine facilitation of dopaminergic transmission.”

“In rats treated for 5 days with amphetamine , concomitant treatment with the dopamine (DA) synthesis inhibitor α-methyl-p-tyrosine prevented the decrease in 3H-binding in corpus striatum, and attenuated the decrease in frontal cortex.”

“The central stimulant actions of only those drugs which have been shown to release endogenous catecholamines amphetamine and ephedrine) are blocked by α-methyltyrosine and enhanced after a chronic diet of this drug is discontinued.”

“A single dose of α-MT markedly reduced the activity response after amphetamine.”

“18 h before death) and in vitro incubation with a‐methyl‐p‐tyrosine (50 μM for 90 min), respectively, reduced the ability of amphetamine (1–100 μM) [in the presence of 30 μM (−)‐sulpiride] to induce release of dopamine and to elevate cyclic AMP accumulation in striatal slices.”