Possible Interaction: Amphetamine and Metyrapone

“Furthermore, non-stressed animals showed an increased locomotor and stereotypy response to amphetamine after treatment with metyrapone.”

“However, the ability of metyrapone treatment to enhance the behavioral (in non-stressed animals) and dopamine release (in non-stressed and stressed animals) responses to amphetamine indicate that chronic metyrapone treatment will produce stimulant sensitization when given alone.”

“ Metyrapone treatment reduced the stress-induced increase in the locomotor, but not stereotypy, response to amphetamine.”

“These findings indicate that metyrapone treatment can reverse, or inhibit the expression of, stress-induced sensitization to the behavioral effects of amphetamine.”

“ Metyrapone pretreatment blocked the memory-enhancing effects of amphetamine , 4-OH amphetamine, and epinephrine but did not affect retention performance of otherwise untreated animals.”

“However, rather than producing attenuation, metyrapone preadministration (3 100 mg/kg) markedly enhanced both the locomotor activating and stereotypy‐inducing actions of d‐amphetamine (dose equivalent to 2.5 mg/kg free base).”