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Last Updated: 2 years ago

Possible Interaction: Amphetamine and Metyrapone

supplement:

Amphetamine

Research Papers that Mention the Interaction

Furthermore, non-stressed animals showed an increased locomotor and stereotypy response to amphetamine after treatment with metyrapone.
However, the ability of metyrapone treatment to enhance the behavioral (in non-stressed animals) and dopamine release (in non-stressed and stressed animals) responses to amphetamine indicate that chronic metyrapone treatment will produce stimulant sensitization when given alone.
Metyrapone treatment reduced the stress-induced increase in the locomotor, but not stereotypy, response to amphetamine.
These findings indicate that metyrapone treatment can reverse, or inhibit the expression of, stress-induced sensitization to the behavioral effects of amphetamine.
Brain Research  •  1998  |  View Paper
Metyrapone pretreatment blocked the memory-enhancing effects of amphetamine , 4-OH amphetamine, and epinephrine but did not affect retention performance of otherwise untreated animals.
Proceedings of the National Academy of Sciences of the United States of America  •  1996  |  View Paper
However, rather than producing attenuation, metyrapone preadministration (3 100 mg/kg) markedly enhanced both the locomotor activating and stereotypy‐inducing actions of d‐amphetamine (dose equivalent to 2.5 mg/kg free base).
Addiction biology  •  1999  |  View Paper