Possible Interaction: Amphetamine and Methadone

“ Methadone withdrawal produces mild symptoms of aggression, and they can be intensified by amphetamine and apomorphine.”

“Electrocardiogram monitoring should be performed among patients who are at risk of frequently using amphetamines during methadone maintenance treatment.”

“These findings suggest that methadone programs indirectly reduce patients' use of cocaine, amphetamines , illegal methadone, tranquilizers, and marijuana, insofar as they are successful in eliminating or decreasing heroin use.”

“Animals treated with methadone for prolonged periods may also develop abnormal movements when challenged with amphetamines.”

“It has been suggested anecdotally that various sedatives, tranquilizers, other depressants and stimulants including alcohol, diazepam, barbiturates, cocaine and amphetamines may have additive, potentiating, or antagonistic effects when taken by methadone maintenance patients.”

“All of the mu opioid agonists and dextrorphan increased amphetamine-induced turning; the coadministration of dextrorphan, levorphanol, meperidine, methadone and morphine with amphetamine produced turning greater than predicted by simple additivity.”

“Perinatal exposure to methadone resulted in tolerance to the thermoregulatory actions of chlorpromazine and amphetamine in at least one sex of each treatment group.”