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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
drug:
Levodopa
Research Papers that Mention the Interaction
“After long-term exposure to amphetamine the startle response to l-dopa and d-amphetamine was enhanced.”
Potentiation of d-amphetamine and l-dopa-induced acoustic startle activity after long-term exposure to amphetamine“Upward jumping in mice that resembled the narcotic-withdrawal syndrome was produced by a combination of amphetamine (4 mg/kg) and L-DOPA (400 mg/kg) administration.”
“RESULTS Le odopa si gnificantly increased gait spe ed an d stride length and decreased the percent of the gait cycle (%GC) spent in double support.”
“We previously found that rats with 6-OHDA lesions, primed with L-DOPA treatment and that have subsequently undergone intrastriatal graft surgery exhibit involuntary movements when subjected to amphetamine.”
Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats“ Amphetamine (1 mg/kg) increased striatal DOPA accumulation, an effect attenuated by R(+)-8-OH-DPAT (0.05 mg/kg).”
“However, following a 6 week withdrawal period, the levodopa animals demonstrated a significant reduction in amphetamine rotations which was reminiscent of control animals.”
“Amantadine, levodopa and apomorphine at lower doses potentiated the rage inducing effect of APT.”
“In addition L-DOPA antagonized the effect of LHRH on acquisition of CARs and counteracted the antagonism between LHRH and amphetamine in acquisition of CARs and SMA.”
“Furthermore, there may be a qualitative change in DA receptors, since L-DOPA is very effective in potentiating these behaviors in cats treated chronically with amphetamine , but is totally ineffective in naive cats.”
“greatly potentiated these behaviors in cats chronically treated with amphetamine , but L-DOPA was totally ineffective in eliciting these behaviors in naive animals.”
“ Amphetamine produced marked anorexia, and l-dopa significantly reduced food intake at 200 mg/kg.”
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