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Last Updated: 3 years ago

Possible Interaction: Amphetamine and Ketamine

supplement:

Amphetamine

Research Papers that Mention the Interaction

Ketamine and amphetamine showed 3 types of interactive effects: (1) amphetamine attenuated the impairment of working memory produced by ketamine; (2) amphetamine and ketamine had additive effects on thought disorder, arousal, and euphoria; and (3) amphetamine and ketamine had less-than-additive effects on psychosis.
Regarding medication development for cognitive dysfunction, the pattern of the interactive effects of ketamine and amphetamine is consistent with the hypothesis that facilitation of prefrontal cortical dopamine levels would attenuate some cognitive impairments associated with deficits in N-methyl-D-aspartate receptor function.
Archives of general psychiatry  •  2005  |  View Paper
More recent studies (9) have demonstrated how ketamine could help to successfully reverse the hypodopaminergic state following acute withdrawal from amphetamine.
The American journal of psychiatry  •  2016  |  View Paper
Our results demonstrate the acute interplay between Amph and Ket in both behavioral and neurochemical aspects for the first time.
The combined ingestion of ketamine Ket ) and amphetamine (Amph) by drug-users has been rampant and produced more severe behavioral abnormality.
Neurotoxicology  •  2013  |  View Paper
Decreased [11C]raclopride binding was demonstrated following amphetamine under ketamine but not under halothane anesthesia.
Neuropsychopharmacology  •  2002  |  View Paper