Possible Interaction: Amphetamine and Insulin

“Conversely, insulin , which activates PI 3‐kinase, increased [3H]DA uptake and blocked the amphetamine‐induced hDAT intracellular accumulation, as did transient expression of constitutively active PI 3‐kinase.”

“We have shown that insulin and its subsequent signaling through the phosphatidylinositol 3-kinase (PI3K)-dependent pathway oppose this effect of AMPH by promoting increased cell-surface expression.”

“Regular exercise, such as a daily 30-minute speedy trot, improves insulin sensitivity.”

“These drugs also significantly reduced food intake in response to injections of insulin and attenuated amphetamine anorexia.”

“Combining treatment with each neuroleptic drug and amphetamine , at the same doses, produced a significant decrease in cerebral levels of insulin (P less than 0.001) as in the amphetamine animals.”

“Rectal absorption of insulin by depancreatized dogs was significantly enhanced by the coadministration of enamine as a suppository adjuvant and if this was followed by a further suppository containing enamine alone, the insulin absorption was even further enhanced.”