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Last Updated: 2 years ago

Possible Interaction: Amphetamine and Imipramine

supplement:

Amphetamine

Research Papers that Mention the Interaction

Imipramine exerted negative dose-response effects on motor performance ( motor speed , motor pursuit), while it improved hyperactive behavior and attention and raised the heart rate slightly.
Perceptual and motor skills  •  1988  |  View Paper
Imipramine increased the amount of physostigmine, but decreased the amount of amphetamine needed for cortical desynchronization.
Imipramine was shown to cause a cortical synchronization, hippocampal desynchronization, rise in the threshold of electrocortical arousal and limbic convulsive activity which was potentiated by amphetamine.
Psychopharmacologia  •  2004  |  View Paper
Imipramine augmented the amphetamine induced stereotype behaviour.
Psychopharmacologia  •  2004  |  View Paper
Both imipramine and cholinesterase inhibitors tested enhanced the hypermotility caused by amphetamine in mice, but not in conditioned rats.
Psychopharmacologia  •  2004  |  View Paper
In general, imipramine was found to potentiate the tendency of amphetamine to increase responding in these situations.
Psychopharmacologia  •  2004  |  View Paper
Imipramine binding to platelet plasma membrane vesicles is competitively inhibited by each of the neurotoxic amphetamines.
Other neurotoxins and amphetamines also inhibited imipramine binding.
Annals of the New York Academy of Sciences  •  1992  |  View Paper
Perfusion of control slices with imipramine decreased the excitatory effect of dopamine, amphetamine , and quinpirole.
Pharmacology Biochemistry and Behavior  •  1991  |  View Paper
Other drugs found to inhibit p-hydroxylation of amphetamine were: imipramine , nortriptyline, protriptyline, Lu 3-010 (ftalan-derivative), chlorpromazine, promethazine, chlorprothixene, prochlorperazine, chlordiazepoxide, diazepam, nialamide and cocaine.
European journal of pharmacology  •  1969  |  View Paper
…,imipramine potentiates the barbiturate sleeping time by inhibiting the metabolic degradation of pentobarbitone (Kato, Chiesara & Vassanelli, 1963), it shows an anti-tremorine … active metabolite, oxotremorine (Sjoqvist & Gillette, 1965 ; Hammer & Sjoqvist, 1966) and it potentiates and prolongs the behavioural and hyperthermic effects of amphetamine (Valzelli, Consolo & Morpurgo, …, Dolfini & others 1967).
The Journal of pharmacy and pharmacology  •  1967  |  View Paper