Possible Interaction: Amphetamine and Imipramine

“ Imipramine exerted negative dose-response effects on motor performance ( motor speed , motor pursuit), while it improved hyperactive behavior and attention and raised the heart rate slightly.”

“ Imipramine increased the amount of physostigmine, but decreased the amount of amphetamine needed for cortical desynchronization.”

“ Imipramine was shown to cause a cortical synchronization, hippocampal desynchronization, rise in the threshold of electrocortical arousal and limbic convulsive activity which was potentiated by amphetamine.”

“ Imipramine augmented the amphetamine induced stereotype behaviour.”

“Both imipramine and cholinesterase inhibitors tested enhanced the hypermotility caused by amphetamine in mice, but not in conditioned rats.”

“In general, imipramine was found to potentiate the tendency of amphetamine to increase responding in these situations.”

“ Imipramine binding to platelet plasma membrane vesicles is competitively inhibited by each of the neurotoxic amphetamines.”

“Other neurotoxins and amphetamines also inhibited imipramine binding.”

“Perfusion of control slices with imipramine decreased the excitatory effect of dopamine, amphetamine , and quinpirole.”

“Other drugs found to inhibit p-hydroxylation of amphetamine were: imipramine , nortriptyline, protriptyline, Lu 3-010 (ftalan-derivative), chlorpromazine, promethazine, chlorprothixene, prochlorperazine, chlordiazepoxide, diazepam, nialamide and cocaine.”

“…,imipramine potentiates the barbiturate sleeping time by inhibiting the metabolic degradation of pentobarbitone (Kato, Chiesara & Vassanelli, 1963), it shows an anti-tremorine … active metabolite, oxotremorine (Sjoqvist & Gillette, 1965 ; Hammer & Sjoqvist, 1966) and it potentiates and prolongs the behavioural and hyperthermic effects of amphetamine (Valzelli, Consolo & Morpurgo, …, Dolfini & others 1967).”