Possible Interaction: Amphetamine and Haloperidol

“Placebo and amphetamine had no effect on qualitative ratings of SPEM, but haloperidol , alone and in combination with amphetamine , disrupted eye tracking, producing a pattern of small saccadic intrusions characteristic of patients with schizophrenia.”

“Finally, haloperidol reduces the number of D2High receptors that are elevated by amphetamine , indicating that this therapeutic effect may occur clinically.”

“Similarly, blockade of B-adrenergic receptors by propranolol and dopamine receptors by haloperidol reversed the circling response elicited by amphetamine.”

“The antistereotypic abilities of haloperidol , fluphenazine and pimozide were most marked against amphetamine , but this was not a consistent observation for thioridazine, clozapine and sulpiride.”

“Low doses of butyrophenones haloperidol and spiroperidol) inhibited the rise in cyclic GMP levels and the stereotyped behaviour induced by amphetamine , but were without effect on the same biochemical and behavioural changes elicited by apomorphine.”

“The rotation induced by amphetamine was significantly antagonized by alphamethyl-p-tyrosine and haloperidol , but not by diethyl-dithiocarbamate.”

“ Haloperidol (0.63–2.5 mg/kg) also blocked the aggression due to mere abstinence or abstinence supersensitized by amphetamine.”

“ Haloperidol at a dosage of 0.1 and 0.05 mg/kg blocked the response to a high dose of amphetamine whereas a lower dose (0.02 mg/kg) blocked the stereotyped response to amphetamine while some exploratory behaviour still took place.”

“In a model of perturbation of cognitive-attentional function, significant latent inhibition was obtained with S 16924 (0.08) and ….16), but not haloperidol (0.0063 and 0.04): higher doses of S 16924 (2.5), clozapine (5.0) and haloperidol (0.1) all blocked … latent inhibition by amphetamine (…).”

“ Haloperidol , a widely used antipsychotic drug, was tested for its ability to block the behavioral response to amphetamine and to elicit catalepsy in rats treated with saline or ascorbic acid (1000 milligrams per kilogram of body weight).”