supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Amphetamine
drug:
Guanethidine
Research Papers that Mention the Interaction
“ D‐amphetamine antagonized the antihypertensive effect of guanethidine in the lying systolic blood pressure, while the orthostatic hypotension persisted.”
Drug interactions with guanethidine“When the effects of 5-HT, reserpine and amphetamine were tested for their ability to enhance efflux of guanethidine and amiloride we found that only amphetamine was active.”
“3 The effect of amphetamine , but not that of NA, was blocked by prior applications of guanethidine or chlorpromazine (CPZ).”
COMPARISON OF THE ELECTROCORTICAL CHANGES INDUCED BY (+)‐AMPHETAMINE AND CHLORPROMAZINE WHEN PERFUSED DIRECTLY INTO THE DORSAL RAPHE NUCLEUS OF THE CAT“ Guanethidine , given instead of protriptyline, only partly prevented the amphetamine induced release of 3H-α-methylnoradrenaline; however, the release from the particulate fraction was completely inhibited.”
“We have further shown that amphetamine produces positive inotropic and chronotropic effects on cat heart depleted of catecholamines by low doses of reserpine, guanethidine and α-methyl tyrosine.”
“The decrease in concentration of cardiac catechol amines produced by guanethidine was prevented by treatment of the animal with bretylium or with 1-phenyl-2-hydrazinopropane (pheniprazine), a monoamine oxidase inhibitor.”
“Promethazine, tyramine, guanethidine , as well as a few anticholinergics, and MAO inhibitors potentiated amphetamine and cocaine, but did not stimulate with tetrabenazine.”
Behavioral effects of interacting imipramine and other drugs with d-amphetamine, cocaine, and tetrabenazine
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback