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Possible Interaction: Amphetamine and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

In cells expressing the concatemer, amphetamine analogs promoted GABA efflux and blunted GABA influx.
Molecular pharmacology  •  2005  |  View Paper
Moreover, amphetamine caused an immediate release of acetylcholine and aspartate and a delayed release of GABA in the nucleus accumbens.
Neurochemical Research  •  2004  |  View Paper
In nucleated outside-out patches, PS depressed peak currents and speeded deactivation after 5 msec applications of a saturating concentration of GABA.
The Journal of Neuroscience  •  2000  |  View Paper
AMPH (5, 10 and 20 microg/microl), infused through a microdialysis probe at the rate of 2.5 microl/min, produced a dose-related increase in extracellular concentrations of GABA.
Neuropharmacology  •  1998  |  View Paper
To explore the role of GABA and NMDA receptor activity in modulating the positive effects of amphetamine on epileptogenesis, alterations in GABA- and NMDA-related convulsions were examined after acute and chronic amphetamine administration.
Brain Research Bulletin  •  1993  |  View Paper
Amphetamine also produced an enhancement on GABA and taurine levels, although these increases did not follow a dose-related curve.
Brain Research Bulletin  •  1993  |  View Paper
The delayed response by GABA to amphetamine may reflect supersensitivity in the activity of postsynaptic gamma-aminobutyric acid-containing neurons in nucleus accumbens as a consequence of the repeated amphetamine treatment.
Thus we suggest that amphetamine decreases extracellular GABA levels by a slow mechanism, associated with the decreased expression of glutamate decarboxylase67 mRNA in a subpopulation of densely labeled neurons in the medial nucleus accumbens.
Neuroscience  •  1992  |  View Paper
Increased motor and behavioral activity after … administration of a large dose of amphetamine were associated with a 2-5-fold increase in the … of glycine in brain, and markedly elevated the concentrations of GABA in the major biogenic amine-containing cell groups … (substantia nigra, locus coeruleus and dorsal raphe).
Neuropharmacology  •  1986  |  View Paper
amphetamine significantly lessened the inhibition of reticulata neurons produced by GABA application.
The Journal of neuroscience : the official journal of the Society for Neuroscience  •  1986  |  View Paper
Locomotor activity from injecting amphetamine unilaterally into the nucleus accumbens was reduced by injections of GABA into the ipsilateral pedunculopontine nucleus.
Brain Research Bulletin  •  1986  |  View Paper
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