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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“In cells expressing the concatemer, amphetamine analogs promoted GABA efflux and blunted GABA influx.”
Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action.“Moreover, amphetamine caused an immediate release of acetylcholine and aspartate and a delayed release of GABA in the nucleus accumbens.”
Dizocilpine Inhibits Amphetamine-Induced Formation of Nitric Oxide and Amphetamine-Induced Release of Amino Acids and Acetylcholine in the Rat Brain“In nucleated outside-out patches, PS depressed peak currents and speeded deactivation after 5 msec applications of a saturating concentration of GABA.”
“ AMPH (5, 10 and 20 microg/microl), infused through a microdialysis probe at the rate of 2.5 microl/min, produced a dose-related increase in extracellular concentrations of GABA.”
“To explore the role of GABA and NMDA receptor activity in modulating the positive effects of amphetamine on epileptogenesis, alterations in GABA- and NMDA-related convulsions were examined after acute and chronic amphetamine administration.”
“ Amphetamine also produced an enhancement on GABA and taurine levels, although these increases did not follow a dose-related curve.”
“The delayed response by GABA to amphetamine may reflect supersensitivity in the activity of postsynaptic gamma-aminobutyric acid-containing neurons in nucleus accumbens as a consequence of the repeated amphetamine treatment.”
“Thus we suggest that amphetamine decreases extracellular GABA levels by a slow mechanism, associated with the decreased expression of glutamate decarboxylase67 mRNA in a subpopulation of densely labeled neurons in the medial nucleus accumbens.”
“Increased motor and behavioral activity after … administration of a large dose of amphetamine were associated with a 2-5-fold increase in the … of glycine in brain, and markedly elevated the concentrations of GABA in the major biogenic amine-containing cell groups … (substantia nigra, locus coeruleus and dorsal raphe).”
“ amphetamine significantly lessened the inhibition of reticulata neurons produced by GABA application.”
“Locomotor activity from injecting amphetamine unilaterally into the nucleus accumbens was reduced by injections of GABA into the ipsilateral pedunculopontine nucleus.”
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