Possible Interaction: Amphetamine and Fenfluramine

“ D‐Amphetamine in combination with D‐fenfluramine increased the critical flicker fusion threshold and in combination with L‐fenfluramine the alerting action was diminished.”

“The differing actions of the fenfluramine isomers and their interactions with D‐amphetamine suggest that D‐fenfluramine is predominantly serotonergic in its activity, whereas L‐fenfluramine may be causing dopamine blockade, reducing certain actions of amphetamine possibly mediated by dopamine receptors.”

“Prior treatment with fenfluramine attenuated the aversive effects of amphetamine , but the converse was found not to be the case.”

“ Fenfluramine was particularly potent in inhibiting amphetamine stimulation and this effect could not be attributed to a reduction of brain levels of amphetamine caused by fenfluramine pretreatment.”

“When fenfluramine instead of saline was offered for self-administration, non-contingent preinjections of amphetamine also increased the response rate.”

“The addition of fenfluramine to amphetamine decreased the maximum responding, at least at the highest dose ratio (1:10, amphetamine/fenfluramine), in all monkeys.”

“the self-administration of the mixture of amphetamine and fenfluramine at a ratio of 1:10 decreased in three monkeys and was unaffected in the fourth.”

“While both fenfluramine and amphetamine resulted in similar overall decreases in caloric intakes, the two drugs produced different effects on nutrient selection.”

“ Amphetamine and fenfluramine in combination effectively suppressed the audiogenic seizures by reversing the neurochemical changes in the striatum in ethanol-dependent rats.”

“Chronic coadministration of amphetamine (2 mg/kg) and fenfluramine (8 mg/kg) reduced alcohol consumption during choice trials in both alcohol-dependent and alcohol-nondependent rats while not affecting water intake.”

“The findings indicate that coadministration of amphetamine and fenfluramine , a treatment effective in reducing alcohol withdrawal seizures, also selectively attenuates alcohol consumption.”

“In another group of animals, pretreatment with piribedil plus amphetamine 30 min before fenfluramine prevented the suppression of ICSS.”

“ Amphetamine (2 mg/kg) + fenfluramine (8 mg/kg) given jointly, but not separately, prevented ethanol withdrawal seizures as effectively as benzodiazepines (chlordiazepoxide), the current drugs of choice.”

“The combination of amphetamine and fenfluramine , unlike chlordiazepoxide, significantly reduced intake of ethanol during and immediately following ethanol withdrawal.”