Possible Interaction: Amphetamine and Estradiol

“Compared with results for OIL, EB enhanced the locomotor-activating effects of repeated 1.0mg/kg amphetamine across treatment days.”

“Our data show that estradiol enhances the DA response to amphetamine.”

“Comparing to control groups, administration of either EB or EB plus AMPH increased DA level (P < 0.01).”

“The protein expression of striatal DAT was significant greater (P < 0.01) in rats treated with AMPH plus EB than AMPH treated animals.”

“These results suggest that the DA levels in striatum can be enhanced by EB via an increase of DAT expression following administration of AMPH.”

“ Estradiol specifically antagonized the amphetamine induced reduction of grooming in the maze only.”

“ Estradiol in the striatum enhances amphetamine (AMPH)- or KCl-stimulated dopamine (DA) release and the pacing of sexual behavior in the female rat.”

“Previous studies have shown that the behavioral activating effects of the stimulant drug amphetamine are augmented in female rats by estradiol.”

“We … particular estradiol , may … amphetamine and morphine, they appear not to be involved in those neurochemical and neuronal changes that occur during and following repeated drug exposures, … to the stimulant effects of a drug seen when such animals are compared with animals receiving the drug for the first time.”

“The fact that female animals were more responsive to … of neonatal T exposure suggests that lifetime exposure to estradiol alters responsiveness to …, and to AMPH , in adult animals and/or that exposure to T both pre- and … necessary for the full suppression of responsiveness seen in adult male animals.”

“Contralateral postural deviation and rotation, induced by unilateral injections of DA and AMPHET into the dorsal striatum, were differentially suppressed with EB treatment.”

“ Amphetamine was capable of further suppressing the release of estradiol release under the presence of nifedipine.”