Possible Interaction: Amphetamine and Epinephrine

“This study demonstrates that amphetamine is an adipokinetic agent causing an increase in the plasma FFA pool of a lesser extent but of longer duration than equipressor doses of epinephrine.”

“Aggregation responses to epinephrine were greatly reduced in the presence of commonly used sympathomimetics such as ephedrine, phenylpropanolamine, and racemic amphetamine that have been found in cold remedies, appetite suppressants, or used in the treatment of attention-deficit hyperactivity disorder, respectively.”

“Drugs such as cocaine and amphetamines potentiate the effect of epinephrine and norepinephrine on the brain and act as stimulants.”

“ Amphetamine could potentiate mucosal contraction induced by norepinephrine or epinephrine.”

“3 Acetylcholine, carbaminoylcholine, eserine, barium and histamine stimulated the muscle, and adrenaline , ephedrine and amphetamine inhibited it.”

“SummaryAdministration of 16 mg/kg of dl-amphetamine sulphate twice daily caused a 3- to 5-fold increase in the urinary output of noradrenaline and adrenaline in rats.”

“RESULTS Prolonged ad enaline ex cess resulted in reduced maximal running spe ed an d shifted T(LA) towards lower exercise intensities than in the control test.”

“The finding that injections of amphetamine and epinephrine have comparable effects on memory is consistent with the view that amphetamine may modulate memory storage, at least in part, by inducing the release of epinephrine from the adrenal medulla.”

“On the other hand, amphetamine produced a smaller increase in liver reducing sugars than that expected from the above correlation and no increase in blood sugar, but elicited a reduction of liver glycogen similar to that produced by the isoanorexigenic dose of adrenaline.”

“These analogs of amphetamine mimic the actions of adrenaline and stimulate the sympathetic nervous system.”