Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Amphetamine and Dopamine



Research Papers that Mention the Interaction

This hypothesis gets major support from the reported d-amphetamine-induced worsening of psychosis, because amphetamine increases dopamine activity in the brain.
Archives of general psychiatry  •  1980  |  View Paper
Finally, in vivo microdialysis experiments showed that amphetamine potentiated orexin A-induced dopamine and glutamate release in the ventral tegmental area (VTA).
Neuropharmacology  •  2019  |  View Paper
Interestingly, while 1 µM AMPH did not cause long-term effects in the LLC-PK1 cells, in the SH-SY5Y cells, it decreased the DA uptake after one, two, but not three, cell divisions and 5-day RA differentiation.
Pretreatments with 50 µM AMPH caused a significant reduction of DA uptake both right after 15 h and 3 cell divisions followed by neuro-differentiation with retinoic acid (RA) for 5 days.
Previous data showed that by binding to catecholamine transporters, AMPH prevents the reuptake of the neurotransmitters dopamine (DA) and norepinephrine (NE).
Neurochemical Research  •  2019  |  View Paper
The same pattern was observed in rats, where an acute injection of amphetamine caused a significant rise in striatal dopamine levels, with no effect of naltrexone pretreatment.
Translational Psychiatry  •  2017  |  View Paper
Dopamine is released in rat brainstem locomotor networks, and amphetamine potentiates dopamine release in vivo.
Proceedings of the National Academy of Sciences  •  2016  |  View Paper
In an ex vivo whole-brain preparation, fluorescent reporters of vesicular cargo and of vesicular pH reveal that amphetamine redistributes vesicle contents and diminishes the vesicle pH-gradient responsible for dopamine uptake and retention.
Nature communications  •  2016  |  View Paper
Consistent with this decrease in surface EAAT3, amphetamine potentiates excitatory synaptic responses in dopamine neurons.
Neuron  •  2014  |  View Paper
Addiction to psychostimulants, including cocaine and amphetamine , is associated with dysregulation of dopamine and serotonin (5-HT) neurotransmitter systems.
Neuropharmacology  •  2014  |  View Paper
Dopamine neurotransmission is increased by acute administration of all drugs of abuse, including the stimulants cocaine and amphetamine.
Frontiers in bioscience  •  2013  |  View Paper
Keltner and Pugh (2007) also note that amphetamines produce a profound effect on the “pleasure pathways” in the brain by enhancing dopamine production.
Perspectives in psychiatric care  •  2010  |  View Paper
Show More