Possible Interaction: Amphetamine and Dexamethasone

“ DM I and II cause slowing down of mental speed , lowering of mental flexibility and DM II learning and memory disturbances.”

“ DEX pretreatment 0, 15, 30, 60 and 120 min before amphetamine or cocaine strongly decreased both amphetamine and cocaine effects, but no dose-related effect was observed.”

“ DEX pretreatment decreased the stimulating effects induced by cocaine and amphetamine.”

“… DEX may play an important regulatory … effects of morphine, cocaine and amphetamine through a differential modulation of brain excitability systems indicating that DEX may play an important role on the stimulating …, cocaine and amphetamine and that it may be of some utility in the clinical management of psychastimuants abuse.”

“Subthreshold doses of phenamine (0.25 mg/kg) given alone had no effect; however, when given on a background of dexamethasone (0.25 mg/kg), phenamine evoked a place preference response in rats lacking an initial place preference for one sector.”

“ Amphetamine (0.4 mg/kg)- or amantadine (50 mg/kg)-induced locomotor hyperactivity was significantly reduced in rats pretreated with dexamethasone at a dose of 8 mg/kg or 4 mg/kg.”

“The results of the experiment demonstrate that prior to administration of prednisolone (4, 6, 10 or 20 mg/kg) or dexamethasone (4 or 8 mg/kg) intensified and prolonged the stereotypy induced by apomorphine (1 mg/kg sc) or amphetamine (2 mg/kg ip).”

“ DEX pretreatment 0, 15, 30, 60 and 120 min before amphetamine or cocaine strongly decreased both amphetamine and cocaine effects, but no dose-related effect was observed.”

“The results indicate that the mechanism of the behavioral effect of DM may be different from that of amphetamine.”

“Treatment with corticosterone or deoxycorticosterone did not reverse the effect of adrenalectomy, whereas dexamethasone completely restored and even potentiated sensitization to amphetamine.”