Possible Interaction: Amphetamine and Desipramine

“It is recommended that desmethylimipramine should be used in combination with one of the analeptic drugs ( amphetamine , ephedrine, methylphenidate, pipradrol), which are the most effective medicaments at present available for attacks of irresistible sleep.”

“During withdrawal from DMI, amphetamine anorexia was attenuated after 2 weeks or 2 months pretreatment, but not after 1 week of treatment.”

“The locomotor stimulant and stereotypy inducing effects of amphetamine were slightly enhanced during withdrawal from chronic DMI.”

“Acute pretreatment with DMI and iprindole enhanced amphetamine anorexia and stereotypy; at high doses only, the enhancement of anorexia disappeared during chronic treatment.”

“The reduction of amphetamine hyperactivity induced by DSP4 was blocked by pretreatment with the noradrenaline-uptake blocking agent, desipramine , which prevents the neurotoxic action of DSP4.”

“PPI is also disrupted by the norepinephrine α-1 agonist, cirazoline, and the PPI-disruptive effects of the indirect dopamine agonist amphetamine are opposed by the norepinephrine reuptake inhibitor, desipramine.”

“ Desipramine attenuated the increase in dopamine by amphetamine while increasing the dopamine released by methamphetamine.”

“ Amphetamine , at intraperitoneal doses of 0.1–3.2 mg/kg, significantly depresses the stimulated motor activity caused by combined treatment with desmethylimipramine ( DMI ) plus tetrabenazine (TBZ) in mice.”

“Our data revealed that after desipramine treatment AMPH injections not only amplified striatal DA release and 2,3-DHBA formation, but also intensified the stereotyped behaviors induced by AMPH.”

“In spontaneously beating rat atria, concentration‐dependent positive chronotropic responses to MDMA and amphetamine were blocked by the neuronaluptake inhibitor desipramine (1 μm) and the β‐adrenoceptor antagonist propranolol (1 μm).”

“MDMA, amphetamine and desipramine each enhanced the electrical stimulation‐induced (2 Hz, 30‐s train) release of radioactivity; the enhancing effects of MDMA and amphetamine were blocked by 1 μm desipramine.”

“The MDMA‐ and amphetamine‐induced release of radioactivity were blocked by 1 μm desipramine.”

“It is concluded that enhancement of the anorexic effect of peripherally administered amphetamine by DMI is primarily a peripheral phenomenon, with interactions within the central nervous system making a relatively minor contribution.”