Possible Interaction: Amphetamine and Cyproheptadine

“On the other hand, the level of amphetamine rose in the brain following premedication with CPH in both doses.”

“ Cyproheptadine inhibited the direct response to serotonin and amphetamine , and the amphetamine-facilitated response to serotonin; it was inactive against dopamine and adrenaline both alone and combined with a facilitating dose of amphetamine or serotonin.”

“In addition, the rate-suppressant effects of the highest doses of amphetamine were also enhanced by cyproheptadine.”

“The combination of cyproheptadine and amphetamine increased response rates to a higher extent than either of the drugs alone.”

“These results show that cyproheptadine can increase nonpunished responding and suggest that cyproheptadine and amphetamine act synergistically, but through different mechanisms, upon multiple fixed-interval fixed-ratio performance.”

“Chlorpromazine or cyproheptadine antagonized the “ amphetamine-state”.”

“6-hydroxydopamine (6-OH-DA) and cyproheptadine (CPH) exerted a lowering effect on blood amphetamine (AMPH) level in rats, at the same time the content of AMPH in the brain was elevated and the simultaneously recorded stereotypy was higher than in controls.”

“This may indicate that CPH premedication causes a rise in AMPH stereotypy mainly by pharmacodynamic interaction, though the elevation of the content of AMPH in the brain after CPH and 6-OH-DA must be of some influence as well.”

“Further, the inhibitory effects of DPI against amphetamine were antagonized by the serotonergic antagonists, methysergide and cypro-heptadine , but not by piperoxan, propranolol or atropine.”