Possible Interaction: Amphetamine and Clozapine

“In contrast, long-term treatment with either d-amphetamine or clozapine produced complex changes in the multiphasic behavioral response to amphetamine , which cannot be explained solely by a shift in the sensitivity of dopamine receptors.”

“In a model of perturbation of cognitive-attentional function, significant latent inhibition was obtained with S 16924 (0.08) … (0.16), but not haloperidol (0.0063 and 0.04): higher doses of S 16924 (2.5), clozapine (5.0) and haloperidol (0.1) … disruption of latent inhibition by amphetamine (…).”

“Thioridazine and clozapine antagonized the increases in locomotion produced by amphetamine , but produced increases in amphetamine-induced stereotypy and lowered the threshold dose for stereotypy.”

“ Clozapine also eliminated the weakening of the caudate responses caused by the stereotypical doses of amphetamine.”

“Single doses of clozapine , risperidone, and pimozide all markedly decreased calling under saline and AMPH.”

“In contrast, repeated clozapine had no effect on extracellular ascorbate in either neostriatum or nucleus accumbens, but increased the locomotor response to an amphetamine challenge.”

“Fourteen-day pretreatment with clozapine (6 mg/kg/day) decreased the duration of amphetamine withdrawal.”

“ CL , a dopamine D4 antagonist, increased the voluntary consumption of amphetamine and morphine with no effects on ethanol or cocaine intake.”

“In addition, clozapine significantly reversed the disruption of LI induced by amphetamine (1.0 mg/kg).”

“ Clozapine (10.0 mg/kg), in contrast, blocked the excitatory effects of amphetamine on all tested neurons and also blocked most amphetamine-induced behaviors within 10 min.”