Possible Interaction: Amphetamine and Clonidine

“ Clonidine was less effective in potentiating amphetamine induced self-biting; the highest dose tested raised the incidence from 28 to 64%.”

“ Clonidine (0.01, 0.05, 0.5 mg/kg) dramatically reduced the locomotor response to amphetamine (2 mg/kg) in a dose related fashion.”

“The lower dose of clonidine reduced amphetamine induced licking/biting while the two higher doses potentiated amphetamine induced licking/biting.”

“Thus the behavioral effects of clonidine vary depending upon the dose of amphetamine and the particular behavior selected for study.”

“Breast feeding with clonidine and amphetamines is therefore contraindicated, but there seems to be no safety concerns for the other drugs.”

“ Clonidine also failed to oppose the PPI-disruptive effects of amphetamine and augmented the PPI-disruptive effects of phencyclidine.”

“In the prostatic portion amphetamine slightly inhibited the peak motor response and attenuated the inhibitory effect of clonidine in both portions of the vas.”

“Our results suggest a specific interaction between amphetamine and clonidine at the α2 receptors, in both the prostatic and epididymal protions of the vas deferens of the rat.”

“Preincubation with …/l amphetamine antagonized … of clonidine (EF 50 amphetamine alone 6.2 Hz, amphetamine + clonidine 7.3 Hz; P>0.5).2.After 12 min of incubation … 0.037 μmol/l the responses to 6.4 Hz (3 s, 0.5 ms) were decreased by 77±2.2%.”

“By contrast, CLON decreased the NE response to 0.5 mg/kg AMPH by 75%, but became progressively less effective on the response as the dose was increased to 1.75 and 5.0 mg/kg.”

“ Amphetamine was 90 times more potent to inhibit [3H]clonidine binding.”

“Binding of [3H]clonidine and [3H]prazosin were inhibited by amphetamine.”

“The results obtained suggest a possible direct interaction between clonidine and amphetamine on alpha-adrenoceptor.”

“The effects of pimozide, clonidine and amphetamine were approximately additive amphetamine cancelled the effects of pimozide and clonidine , while clonidine augmented the effect of pimozide).”

“Although amphetamine and clonidine may share some elements in common, this may not represent a noradrenergic component in the amphetamine discriminative stimulus since noradrenergic mediation of the clonidine stimulus was not established.”

“The similarity between the discriminable properties of amphetamine and clonidine was both partial and asymmetrical.”

“ Amphetamine proved able to reverse the effects of clonidine and furthermore, clonidine attenuated the behavioural and EEG changes due to amphetamine.”