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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
drug:
Cholecystokinin
Research Papers that Mention the Interaction
“Administration of cholecystokinin against a background of phenamine and 5-hydroxytryptophan briefly entirely inhibited the behavioral effects induced by these substances.”
Intracerebroventricular administration of cholecystokinin inhibits the activity of the dopaminergic and serotoninergic systems of the brain“These results suggest that endogenous CCK , released during exploratory activity, shapes behavioral responses to amphetamine by acting on both receptor subtypes, and modulates the development of sensitization to amphetamine.”
“3 Plasma CCK levels were increased dose‐dependently by amphetamine.”
“ CCK enhanced the locomotor stereotypy produced by amphetamine without affecting any of the other behaviors recorded.”
“ Cholecystokinin suppressing markedly dopamine and serotonin turnover in various brain structures, completely blocked the behavioral effects of amphetamine (2.5 mg/kg) and 5-hydroxytryptophan (150 mg/kg).”
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