Possible Interaction: Amphetamine and Chlordiazepoxide

“ Chlordiazepoxide antagonized both effects of amphetamine.”

“Thus the effects of all three drugs depended upon the control rates of responding, but the effects of amphetamine were the inverse of those of CDP and morphine.”

“ Chlordiazepoxide , which produced a release of punished responding by itself, also reversed the suppression of punished responding produced by CRF but not that of amphetamine.”

“Haloperidol (HAL), chlorpromazine (CPZ), morphine (MOR), pentobarbital (PENT), chlordiazepoxide (CDP), meprobamate (MPB), and amphetamine (AMPH) dose dependently inhibited both behaviors.”

“Coadministration of amphetamine (0.2 mg/kg) and CDP (0.4 mg/kg) had a significant anti-conflict effect.”

“The disinhibitory effects of amphetamine coadministered with CDP were discussed in terms of a possible enhanced noradrenergic or dopaminergic activity and their interaction with GABA neurotransmission at GABA-benzodiazepine coupled sites.”

“ Amphetamine , 1 mg/kg, usually did not facilitate significantly the responding, but its combination with chlordiazepoxide produced a stronger and more pronounced effect than that of chlordiazepoxide alone.”

“Thus, during time out no specific effects were observed following morphine, amino-oxyacetic acid, caffeine or para-chlorophenylalanine (PCPA), although amphetamine , chlordiazepoxide ( CDP ) and diazepam (DZP) produced dose dependent changes in lever pressing rate.”

“Other drugs found to inhibit p-hydroxylation of amphetamine were: imipramine, nortriptyline, protriptyline, Lu 3-010 (ftalan-derivative), chlorpromazine, promethazine, chlorprothixene, prochlorperazine, chlordiazepoxide , diazepam, nialamide and cocaine.”

“Both saponins inhibit the spontaneous motility of mice, even at low doses (1 mg/ kg), they show an antagonistic effect on amphetamine and exert a synergistic activity on chlordiazepoxide.”