Possible Interaction: Amphetamine and Central Nervous System Stimulants

“Converging evidence indicates that repeated exposure to motor stimulants such as cocaine and amphetamine produces marked alterations in network responsiveness of striatal neurons to subsequent challenge with the same stimulant drug.”

“In recent years, use of cocaine and amphetamines and deaths associated with stimulants have been on the rise, and there are still no FDA-approved medications for stimulant use disorders.”

“These results demonstrate that intranasal administration of d‐amphetamine results in a more rapid onset compared to oral dosing, which could be associated with the popularity of intranasal prescription stimulant use and an enhanced potential for abuse.”

“Drugs such as cocaine and amphetamines potentiate the effect of epinephrine and norepinephrine on the brain and act as stimulants.”

“Abuse of amphetamine and especially the stimulant look-alikes represent a serious problem in the United States.”

“It is not a central excitant, but rather is an antagonist of central stimulation produced by other agents in the mouse, including amphetamine , morphine, cocaine, and Meratran.”

“The results suggest that amphetamine co-use may mask physical signs of alcohol dependency and add to the importance of educational strategies pointing out the potential problems associated with co-use of stimulants and alcohol.”

“The development of the dopamine input to the medial prefrontal cortex occurs during adolescence and is a process that is vulnerable to disruption by stimulant drugs such as amphetamine.”

“These findings indicate that administration of the stimulant during the waking cycle compared to sleep cycle may significantly increase the potency of amphetamines to produce hyperthermia, neurotoxicity and lethality.”

“Collectively, these data suggest that repeated AMPH exposure can lead to persistent disruption of dopaminergic modulation of BLA–mPFC circuitry, which may underlie impairments in cognitive/emotional processing observed in stimulant abusers.”