Possible Interaction: Amphetamine and Caffeine

“ Caffeine increased both tapping speed tests (p = 0.041 and 0.010, respectively) in comparison with placebo treatment.”

“ Caffeine also dose-dependently increased the frequency of stimulant identifications on the Pharmacological Class Identification Questionnaire (e.g., like cocaine, amphetamine).”

“Rodent models suggest that amphetamines and cocaine interact with different pathways to that affected by caffeine.”

“ Caffeine and amphetamine have been regarded as dramatically dissimilar drugs, both structurally and behaviorally.”

“Chronic administration of caffeine and amphetamine induces a block of the population growth; different components of aggressiveness can be identified as responsible.”

“Based on previous findings with amphetamine , we predicted that caffeine would increase willingness to exert effort.”

“Drugs can affect time: Caffeine and thyroxine decrease the estimation of time, and amphetamines , marijuana, and opium increase it.”

“A 37 year-old man with an ischaemic stroke after the nasal use of amphetamine and caffeine is reported.”

“Despite much variation in their methodologies, these studies broadly agreed that schizophrenic groups' use of amphetamines and cocaine, cannabis, hallucinogens, inhalants, caffeine , and tobacco was significantly greater than or equal to use by control groups consisting of other psychiatric patients or normal subjects.”

“Moreover, individual susceptibility to caffeine and development of motor behaviour sensitization were correlated to the behavioural response obtained after a challenge with amphetamine.”

“Moreover, caffeine pretreatment potentiated the behavioural effects of amphetamine according to the degree of caffeine sensitization but not to individual susceptibility to acute caffeine.”