Possible Interaction: Amphetamine and Bupropion

“Three double-blind placebo-controlled trials using modafinil, bupropion and naltrexone have shown positive results in reducing amphetamine or methamphetamine use.”

“Naltrexone and bupropion , when administered alone in clinical trials, modestly reduce amphetamine use.”

“Therapeutic use of bupropion appears to be the most frequent cause of false positive urine drug screens for amphetamines in our population.”

“ Amphetamine , atomoxetine, clonidine and guanfacine only have case series to support their use and bupropion should be avoided.”

“Using gas chromatography/mass spectrometry (GC/MS), and liquid chromatography/mass spectrometry (LC/MS), the authors identified bupropion , a drug used to aid in smoking cessation, as the interfering compound, which may cause false-positive results for amphetamines and LSD using the CEDIA assays.”

“Based on its efficacy in drug addiction, we also asked if bupropion could block the effect of amphetamine.”

“ Bupropion dose-dependently decreased responding for sucrose and amphetamine.”

“ BUP promotes ambulation in mice and causes behavioral sensitization on the ambulation-promoting effect when repeatedly administered as well as AMPH and MetAMPH.”

“One rTMS-induced seizure was reported from the Food and Drug Administration in a sleep-deprived patient who was concurrently taking bupropion , sertraline, and amphetamine.”