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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
drug:
Bretylium
Research Papers that Mention the Interaction
“In the presence of bretylium , the inhibition by amphetamine of the stimulation-evoked release of [3H]dopamine was still present.”
Amphetamine inhibits the electrically evoked release of [3H]dopamine from slices of the rabbit caudate.“6 The close arterial injection of (+)‐amphetamine sulphate (100 μg) after bretylium (2–4 mg) partially restored the output of noradrenaline and contractions of the spleen to both nerve stimulation and acetylcholine.”
“Further, Matsumoto & Horita (1962) and Day (1962) have shown that the adrenergic neurone blocking effect of bretylium is reversed by amphetamine.”
“It is interesting in this connection that Brodie, Chang & Costa (1965) showed that the uptake of bretylium in the rat heart was inhibited by amphetamine although it was not made certain whether the inhibition of bretylium binding is associated directly with the antagonism of adrenergic neurone blockade.”
“On the other hand, the anti-hypertensive effect of bretylium is antagonized by amphetamine (Wilson & Long, 1960).”
“Responses to tyramine and amphetamine are also affected by bretylium ; but only when the drug has been administered for several weeks does the degree of depression equal that seen 24 hr.”
Adrenergic Neurone-blocking Agents related to Choline 2,6-Xylyl Ether Bromide (TM 10), Bretylium and Guanethidine
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