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Last Updated: 3 months ago

Possible Interaction: Amphetamine and Bretylium

supplement:

Amphetamine

Research Papers that Mention the Interaction

In the presence of bretylium , the inhibition by amphetamine of the stimulation-evoked release of [3H]dopamine was still present.
The Journal of pharmacology and experimental therapeutics  •  1983  |  View Paper
6 The close arterial injection of (+)‐amphetamine sulphate (100 μg) after bretylium (2–4 mg) partially restored the output of noradrenaline and contractions of the spleen to both nerve stimulation and acetylcholine.
British journal of pharmacology  •  1968  |  View Paper
Further, Matsumoto & Horita (1962) and Day (1962) have shown that the adrenergic neurone blocking effect of bretylium is reversed by amphetamine.
It is interesting in this connection that Brodie, Chang & Costa (1965) showed that the uptake of bretylium in the rat heart was inhibited by amphetamine although it was not made certain whether the inhibition of bretylium binding is associated directly with the antagonism of adrenergic neurone blockade.
On the other hand, the anti-hypertensive effect of bretylium is antagonized by amphetamine (Wilson & Long, 1960).
The Journal of pharmacy and pharmacology  •  1965  |  View Paper
Responses to tyramine and amphetamine are also affected by bretylium ; but only when the drug has been administered for several weeks does the degree of depression equal that seen 24 hr.
Nature  •  1961  |  View Paper