Possible Interaction: Amphetamine and Baclofen

“Both GS39783 (30 and 100 mg/kg) and baclofen (1.25 mg/kg), significantly blocked the expression of amphetamine CPP without affecting locomotor activity.”

“After the last treatment, levels of cAMP and phosphorylated (p) cyclic‐AMP response element binding protein (CREB) were up‐regulated in the striatum … somatosensory cortex of Amph‐treated WT mice, while similar to the saline‐controls in the baclofen+Amph‐treated group, indicating the blockade by baclofen to Amph.”

“The GABAB agonist baclofen BCF ) has recently been reported to block the expression of sensitization to the locomotor effect of amphetamine (AMPH), and to reverse it after repeated administration.”

“At 2.5 mg/kg, baclofen did not alter spontaneous motor activity or total distance traveled, but completely blocked vertical rearing induced by amphetamine.”

“At 5.0 mg/kg, baclofen completely blocked both total distance traveled and vertical rearing induced by amphetamine.”

“The ability of the GABAB agonist baclofen and the GABA transaminase inhibitor sodium valproate to block the enhanced distractibility produced by amphetamine was evaluated in a procedure especially designed for analyzing drugs' effects on distractibility.”

“In a previous report, we demonstrated that intra-A10 injections of baclofen , a gamma-aminobutyric acidB agonist, could inhibit the motor-stimulant response to cocaine and amphetamine.”

“ Baclofen also prevented the motor stimulant response to peripheral injection of cocaine or amphetamine , but was ineffective in blocking caffeine-induced behavioral activity.”

“ Baclofen reduced the stimulating action of quipazine and LSD, had no effect on the clonidine-induced reflex stimulation, but inhibited the flexor reflex stimulation induced by amphetamine and fenfluramine.”

“ Amphetamine almost completely inhibited the rise in dopamine produced by baclofen.”