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Last Updated: 2 years ago

Possible Interaction: Amphetamine and Baclofen



Research Papers that Mention the Interaction

Both GS39783 (30 and 100 mg/kg) and baclofen (1.25 mg/kg), significantly blocked the expression of amphetamine CPP without affecting locomotor activity.
Addiction biology  •  2011  |  View Paper
After the last treatment, levels of cAMP and phosphorylated (p) cyclic‐AMP response element binding protein (CREB) were up‐regulated in the striatum … somatosensory cortex of Amph‐treated WT mice, while similar to the saline‐controls in the baclofen+Amph‐treated group, indicating the blockade by baclofen to Amph.
Synapse  •  2006  |  View Paper
The GABAB agonist baclofen BCF ) has recently been reported to block the expression of sensitization to the locomotor effect of amphetamine (AMPH), and to reverse it after repeated administration.
Behavioural pharmacology  •  2005  |  View Paper
At 2.5 mg/kg, baclofen did not alter spontaneous motor activity or total distance traveled, but completely blocked vertical rearing induced by amphetamine.
At 5.0 mg/kg, baclofen completely blocked both total distance traveled and vertical rearing induced by amphetamine.
Brain Research  •  2004  |  View Paper
The ability of the GABAB agonist baclofen and the GABA transaminase inhibitor sodium valproate to block the enhanced distractibility produced by amphetamine was evaluated in a procedure especially designed for analyzing drugs' effects on distractibility.
Pharmacology Biochemistry and Behavior  •  1997  |  View Paper
In a previous report, we demonstrated that intra-A10 injections of baclofen , a gamma-aminobutyric acidB agonist, could inhibit the motor-stimulant response to cocaine and amphetamine.
The Journal of pharmacology and experimental therapeutics  •  1992  |  View Paper
Baclofen also prevented the motor stimulant response to peripheral injection of cocaine or amphetamine , but was ineffective in blocking caffeine-induced behavioral activity.
The Journal of pharmacology and experimental therapeutics  •  1990  |  View Paper
Baclofen reduced the stimulating action of quipazine and LSD, had no effect on the clonidine-induced reflex stimulation, but inhibited the flexor reflex stimulation induced by amphetamine and fenfluramine.
Polish journal of pharmacology and pharmacy  •  1979  |  View Paper
Amphetamine almost completely inhibited the rise in dopamine produced by baclofen.
Acta pharmacologica et toxicologica  •  1977  |  View Paper