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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
drug:
Atropine
Research Papers that Mention the Interaction
“While equimolar doses of methyl atropine failed to completely reproduce the effects of atropine … in an avoidance task, Carlton was apparently puzzled by the finding that "MeA, like atropine , augmented the … of amphetamine and that it produced an atropine-like slowing … the EEG" (Carlton and Didamo 1961, p 586).”
Central versus peripheral effects of muscarinic antagonists: the limitations of quaternary ammonium derivatives“ Atropine induced sniffing and increased the response of both amphetamine and nicotine.”
“It was found that the increase in CoBF induced by amphetamine is blocked by atropine or chlorpromazine.”
On the mechanism of the amphetamine induced vasodilatation at the rat's cerebral cortex“Doses of atropine , Tremorine, eserine, and 4-(1-naphthylvinyl)-pyridine (NVP), an inhibitor of the enzyme choline acetylase, which were ineffective in themselves, markedly affected the increase in rate observed after amphetamine.”
“ Atropine potentiated the effect of pre-trial amphetamine on performance during the first-day session, but it partly antagonised that of post-trial amphetamine on retention.”
“Thus, amphetamine was considered to have a dual effect on behaviour: on one hand, an enhancing effect on pseudoconditioning, which could be potentiated by atrophie; on the other, another stimulant action on memory consolidation, which was counteracted by atropine.”
“Unlike pilocarpine, atropine (10 mg/kg intraperitoneally significantly increases the intensity of the circling behaviour induced by amphetamine and also to some extent that induced by apomorphine.”
“Although each treatment increased heart rate significantly during the resting state, only the amphetamine plus atropine treatment increased heart rate significantly during exercise.”
“Fewer ectopic beats were found when atropine was used with amphetamine.”
“4 The effect of atropine and arecoline on the duration of EADs, previously described, were not modified by the α‐adrenoceptor blocking drugs, but atropine prevented and reversed the inhibitory action of amphetamine.”
“The fall in blood pressure produced by atropine after amphetamine might be due to weak alpha-adrenoceptor blockade.”
“Doses of atropine , ineffective in themselves, markedly augmented the increases in rate observed after amphetamine as well as the duration of these increases.”
Augmentation of the behavioral effects of amphetamine by atropine.
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