Possible Interaction: Amphetamine and Ascorbate

“Systemic, intraventricular, or intraneostriatal ascorbate administration, for example, attenuates the behavioral effects of amphetamine and potentiates the behavioral response to haloperidol.”

“Numerous biochemical and behavioural tests have shown that ascorbate antagonizes the effects of amphetamine and enhances the effects of the antipsychotic drug haloperidol.”

“In order to evaluate the effects of ascorbate, which is known to modulate dopamine neurotransmission, on the reinforcing effects of amphetamine, we coadministered ascorbate and amphetamine during the acquisition of conditioned place preference (CPP) in rats.”

“Abstract: In the neostriatum, amphetamine and other dopamine agonists elevate the extracellular level of ascorbate , which is known to modulate neostriatal function.”

“Our results implicate both of these sites in amphetamine‐induced increases in the release of neostriatal ascorbate.”

“ Amphetamine and other dopamine agonists elevate the extracellular level of neostriatal ascorbate , which has been shown to modulate neuronal function.”

“The ability of amphetamine to alter the extracellular level of ascorbate , an apparent modulator of neostriatal function, was assessed voltammetrically in the neostriatum and nucleus accumbens of awake, behaving rats.”

“Unilateral nigral infusion of dopamine or amphetamine leads to a significant increase in the concentrations of ascorbate detected bilaterally in the caudate nuclei with in vivo electrochemistry.”