Possible Interaction: Amphetamine and Apomorphine

“Rotation was not necessarily in the same direction with high and low doses of amphetamine, or amphetamine and apomorphine administered a week apart from each other.”

“Administration of apomorphine (0.5 mg/kg) and amphetamine (2.5 mg/kg) after chronic low dose apomorphine treatment revealed an enhancement of their effects - stereotypy and aggressiveness was observed.”

“ Apomorphine and amphetamine caused turning behaviour in the lesiond animals which was ipsiversive after DR lesions but contraversive after MR damage.”

“Prolonged pretreatment with suprathreshold doses of amphetamine decreased the threshold dosage of both amphetamine and apomorphine necessary to elicit stereotyped behavior.”

“The altered effects of apomorphine and amphetamine could indicate differential changes in dopamine receptor signalling leading to functional desensitisation, or altered modulation of sensory gating in the nucleus accumbens by limbic structures such as the hippocampus.”

“However, an asymmetry in turning was observed both under apomorphine and amphetamine , that is, turning away from the dominant vibrissae side.”

“Low doses of apomorphine (0.1 and 0.2 mg/kg) markedly antagonized the initial locomotor increase by amphetamine but only incompletely antagonized the amphetamine-induced stimulation 15–30 min after the start of the recording.”

“Some differences in the behavioural patterns after injection of amphetamine and apomorphine were observed.”

“Twenty-one days post unilateral stereotaxic injection of Tinuvin 123, systemic injection of both apomorphine and amphetamine caused rotations toward the side of the lesion in these rats.”

“In a second series of experiments, we sought to determine whether priming with these … selective dopamine receptor agonists, as well as the mixed D1/D2 agonist, apomorphine , would result in an enhanced stereotypy response to … subsequent administration of non-stereotypy producing doses of amphetamine (0.5-1.… mg/kg).”