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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Amodiaquine and Glutathione



Research Papers that Mention the Interaction

A previous study reported that a combination of high dose AQ and glutathione (GSH) depletion led to liver injury.
Journal of immunotoxicology  •  2016  |  View Paper
This differential effect is explained by the ability of chloroquine and amodiaquine to inhibit the degradation of membrane-associated FP by glutathione and the incapacity of quinine and mefloquine to do so.
Molecular and biochemical parasitology  •  1999  |  View Paper
In this assay, 50 microM of amodiaquine , arthemether, chloroquine, methylene blue, mefloquine and quinine inhibited the interaction between glutathione (50 microM) and heme (50 microM), while atovaquone did not.
Experimental parasitology  •  2007  |  View Paper
AQ , MQ and HF decreased significantly the GSH level, GST activity and increased the formation of MDA.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP  •  2000  |  View Paper