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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amodiaquine
supplement:
Glutathione
Research Papers that Mention the Interaction
“A previous study reported that a combination of high dose AQ and glutathione (GSH) depletion led to liver injury.”
Exploring an animal model of amodiaquine-induced liver injury in rats and mice“This differential effect is explained by the ability of chloroquine and amodiaquine to inhibit the degradation of membrane-associated FP by glutathione and the incapacity of quinine and mefloquine to do so.”
“In this assay, 50 microM of amodiaquine , arthemether, chloroquine, methylene blue, mefloquine and quinine inhibited the interaction between glutathione (50 microM) and heme (50 microM), while atovaquone did not.”
A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.“ AQ , MQ and HF decreased significantly the GSH level, GST activity and increased the formation of MDA.”
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