Possible Interaction: Amobarbital and NADH

“Furthermore, titrations with Amytal , an inhibitor of NADH :CoQ oxidoreductase, revealed mild mitochondrial dysfunction in skeletal muscle tissue, which was described in patients with MND in an earlier report.”

“Oxidation of NADH was prolonged upon treatment with amobarbital , whereas no change in NADH oxidation was observed with malonate and nicotinamide.”

“Inhibition of hydrogen transfer between NADH and Co Q by rotenone or amytal in salivary gland cells of Drosophila hydei maintained in vitro, results in the activation of a particular group of four loci in the polytene chromosomes (puff formation).”

“The NADH oxidation occurred in the respiratory chain and it was selectively blocked by Amytal.”

“The addition of NADH to reaction mixtures containing a NADPH-generating system increased the maximum velocities of amobarbital , hexobarbital, and pentobarbital by 77, 249, and 47%, respectively.”

“ Amytal and rotenone specifically blocked NADH oxidation, and respiration was also inhibited by KCN, antimycin A and thenoyltrifluroacetone.”

“ Amytal partially inhibited the reduction of added cytochrome c by NADH 2 and had no effect on the reduction by malate.”

“The formation of DPNH is inhibited by Amytal , but not by oligomycin.”

“The rate of DPNH oxidation by oxygen is slightly inhibited by the addition of amytal , antimycin, or cyanide and greatly increased by cytochrome c. In the presence of cytochrome c, DPNH oxidation is potently inhibited by cyanide.”

“ Amytal partially inhibits oxidation of NADH but not phosphorylation.”