Possible Interaction: Amobarbital and Glucose

“Addition of 2 mM amytal markedly decreased the islet energy level and eliminated the secretory response to 16 mM glucose.”

“With the latter substrate, in the presence of Amytal , the rates of mitochondrial ATP production were higher than those with glucose as the substrate.”

“Treatment with amobarbital (0.16 mmol/kg) decreased the incorporation of glucose into acetylcholine by 73 × 7%, and treatment with atropine increased it by 18 × 6%.”

“In the presence of amobarbital (used to preserve the function of the alpha-GOP shuttle under conditions where oxidation of NADH by the respiratory chain was blocked), glucose increased insulin secretion, O2 consumption, and the cell [ATP]/[ADP] when compared with amobarbital alone.”

“Rotenone, cyanide and amytal also produce a rapid efflux of glucose from the membrane vesicles.”

“In primary cells increased inhibition of O 2 uptake by Amytal is obtained in the presence of glucose , despite the fact that addition of glucose to non-inhibited cells increase O 2 uptake, while addition of palmitate to Amytal-inhibited cells increases O 2 uptake.”