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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ammonium Chloride
supplement:
Ornithine
Research Papers that Mention the Interaction
“ Ammonium chloride injection caused … in ornithine (Orn) 5 min after injection and an increase in the sum of Orn, citrulline (Cit) and arginine (Arg) for at least 15 … in the liver of control mice, but no increase in Orn, Cit and Arg in the liver of spf-ash mice.”
Aberrations of ammonia metabolism in ornithine carbamoyltransferase-deficient spf-ash mice and their prevention by treatment with urea cycle intermediate amino acids and an ornithine aminotransferase inactivator.“ Ornithine and arginine, which stimulate urea synthesis, strongly inhibited urea-stimulated GSA synthesis in the presence of 10 mM ammonium chloride , but the inhibitory effect of ornithine was not observed when ammonium chloride was not present.”
“In term fetuses, the rate of urea formation increases with ammonium chloride concentration up to 100 microM and is enhanced by the addition of ornithine.”
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