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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Ammonium Chloride and Alpha-Ketoglutaric Acid

Research Papers that Mention the Interaction

At concentrations greater than 0.3 M , ammonium chloride inhibits the reductive animation of both α-ketoglutarate and pyruvate.
Archives of biochemistry and biophysics  •  1963  |  View Paper
Since α-ketoglutarate was extremely active in promoting growth in a medium containing ammonium chloride it was implied that the ammonia may be fixed by L-glutamic acid dehydrogenase activity, especially since this particular enzyme was located in these organisms.
Canadian journal of microbiology  •  1955  |  View Paper