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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ammonia
supplement:
Tryptophan
Research Papers that Mention the Interaction
“ Ammonia , in addition to exerting potential toxic effects on the pineal gland [12], results in an increased entry of tryptophan into the brain, with alterations of serotonin (precursor of melatonin) and associated neurotransmission [13].”
Disruption of the Diurnal Rhythm of Plasma Melatonin in Cirrhosis“Hypothalamic concentrations of tyrosine and tryptophan were increased by the ammonia infusion and reduced significantly in insulin-treated infused rats.”
Insulin reverses ammonia-induced anorexia and experimental cancer anorexia.“Although Tk-TrpE displayed 47.6% similarity with TrpE of Salmonella typhimurium, conserved amino acid residues proven to be essential for inhibition of …, Met293, and Cys465 in the enzyme from S. typhimurium were replaced by Arg28, Thr221, and Ala384 in Tk-TrpE. Nevertheless, significant inhibition by L-tryptophan … ammonia ….”
Anthranilate synthase without an LLES motif from a hyperthermophilic archaeon is inhibited by tryptophan.
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