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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ammonia
supplement:
Resveratrol
Research Papers that Mention the Interaction
“ RSV and LA were able to prevent the oxidative damage induced by ammonia , maintaining the levels of ROS production and GSH close to basal values.”
Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1.“ Ammonia also induced DNA damage that was prevented by resveratrol , indicating its genoprotective effect.”
“Results: We showed that resveratrol prevented the increase in ROS production, the decrease of mitochondrial membrane potential (ΔΨm), and bioenergetics deficit caused by ammonia in C6 astroglial cells.”
Resveratrol prevents ammonia-induced mitochondrial dysfunction and cellular redox imbalance in C6 astroglial cells“ Resveratrol … ammonia : (i) decrease in glutamate uptake activity and expression of the EAAC1 glutamate transporter, the main glutamate transporter present in C6 cells; (ii) increase of … Na(+)-K(+)-Cl(-) co-transporter NKCC1; (iii) reduction in GS activity and intracellular GSH content; and (iv) impairment of Na(+)K(+)-ATPase activity.”
“We previously described that resveratrol is able to significantly modulate glial functioning and has a protective effect during ammonia challenge in vitro.”
“ Resveratrol prevented ammonia toxicity by modulating oxidative stress, glial and inflammatory responses.”
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