Possible Interaction: Ammonia and Potassium

“In addition, the close relationship between potassium levels and ammonia production dictates that hyperkalemia per se can lead to acidosis.”

“These observations suggest that changes in potassium modulate ammonia production , which in turn maintains hydrogen ion homeostasis and influences potassium excretion.”

“In the collecting duct, ammonia decreases potassium secretion and stimulates potassium reabsorption, thereby decreasing urinary potassium excretion and enabling feedback correction of the initiating hypokalemia.”

“A negative correlation was found between the deltas of ammonia and potassium (r = −0.74, p < 0.001) in the HF group.”

“Using a combination of two-photon imaging and electrophysiology in awake headrestrained mice, we show that ammonia rapidly compromises astrocyte potassium buffering, increasing extracellular potassium concentration and overactivating the Na-K22Cl cotransporter isoform 1 (NKCC1) in neurons.”

“Using a combination of two-photon imaging and electrophysiology in awake head-restrained mice, we show that ammonia rapidly compromises astrocyte potassium buffering, increasing extracellular potassium concentration and overactivating the Na+-K+-2Cl− cotransporter isoform 1 (NKCC1) in neurons.”

“These results suggest that luminal potassium concentration has a direct effect on cell-to-lumen transport of ammonia.”

“Subcutaneous injection of 10 mg/kg of potassium cyanide increased the levels of blood ammonia by 2.5-fold as compared to those of the corresponding controls and caused loss of consciousness in 100% of the treated mice.”

“Total production of ammonia was lowest in the animals given a potassium supplement where muscle potassium decreased much less than in the other chronic animals.”

“At high sodium and potassium concentrations, the toxicity of ammonia was reduced to the point where un-ionized ammonia concentrations also affected toxicity, and the LC50 became pH dependent.”