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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ammonia
supplement:
Orotic Acid
Research Papers that Mention the Interaction
“Administration of either ammonia or glycine to both rats and mice results in an increased synthesis in the liver and urinary excretion of orotic acid.”
Cycloheximide sensitivity of orotic acid biosynthesis induced by ammonia and glycine administration.“For example, increased administration of amino acids, ammonia , certain disturbances in urea cycle enzymes and/or metabolites, and certain types of liver dysfunction result in increased synthesis of orotic acid.”
“The blood ammonia level was reduced by 47% when orotic acid was used instead of acetic acid.”
“ Ammonia , the only nitrogen source utilized by CPSase-I, markedly stimulated the incorporation of NaH14CO3 into orotic acid in liver slices, and ornithine, which enhances the intramitochondrial consumption of carbamoylphosphate (CP) in citrulline synthesis, antagonized the stimulation by ammonia.”
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