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Last Updated: 4 months ago

Possible Interaction: Ammonia and Ornithine





Research Papers that Mention the Interaction

Blood ammonia rose with ornithine load, while ornithine levels were twice that of controls.
Diabete & metabolisme  •  1975  |  View Paper
Supplementary ornithine or arginine lowers plasma ammonia levels and simultaneously decreases the excretion of homocitrulline.
American journal of diseases of children  •  1974  |  View Paper
The binding of ornithine was inhibited by UMP and ammonia , enhanced by MgATP, MgADP, and IMP, and not affected by bicarbonate, L-glutamine, or ATP (Mg2+ absent).
Biochemistry  •  1977  |  View Paper
Ammonia also modulates BBB transport of the cationic amino acids: the nitric oxide precursor, arginine, and ornithine , which is an ammonia trap, and affects the transport of energy metabolites glucose and creatine.
Neurotoxicity Research  •  2011  |  View Paper
It has been shown in vitro, in vivo and in perfused organs that urea synthesis from ammonia is limited by endogenous ornithine and that ornithine can pharmacologically promote urea formation to a greater degree than any ammonia supply.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego  •  2010  |  View Paper
The data indicate an increased detoxification rate of ammonia by arginine and ornithine supplementation.
Toxins  •  2018  |  View Paper
We also observed that the combination of hyperammonemia with ornithine resulted in significant decreases of sulfhydryl levels, reduced glutathione (GSH) concentrations and the activities of catalase (CAT) and glutathione peroxidase (GPx), highlighting a synergistic effect of ornithine and ammonia.
Metabolic Brain Disease  •  2012  |  View Paper
It is concluded that in sheep hepatocytes both ornithine and propionate stimulate the utilization of ammonia for urea synthesis and these effects take place independently and occur by different mechanisms.
The International journal of biochemistry  •  1990  |  View Paper
The amount of reduction in blood ammonia by ornithine and arginine compounds was less the longer the preinfusion of NH4.
Metabolic Brain Disease  •  1989  |  View Paper
However, the transport activity of ornithine was increased to a maximum after 4 hr of incubation with ammonia , and then decreased gradually to twice the control level.
The Tohoku journal of experimental medicine  •  1989  |  View Paper
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