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Possible Interaction: Ammonia and Ornithine

drug:

Ammonia

supplement:

Ornithine

Research Papers that Mention the Interaction

Blood ammonia rose with ornithine load, while ornithine levels were twice that of controls.
Diabete & metabolisme  •  1975  |  View Paper
Supplementary ornithine or arginine lowers plasma ammonia levels and simultaneously decreases the excretion of homocitrulline.
American journal of diseases of children  •  1974  |  View Paper
The binding of ornithine was inhibited by UMP and ammonia , enhanced by MgATP, MgADP, and IMP, and not affected by bicarbonate, L-glutamine, or ATP (Mg2+ absent).
Biochemistry  •  1977  |  View Paper
Ammonia also modulates BBB transport of the cationic amino acids: the nitric oxide precursor, arginine, and ornithine , which is an ammonia trap, and affects the transport of energy metabolites glucose and creatine.
Neurotoxicity Research  •  2011  |  View Paper
It has been shown in vitro, in vivo and in perfused organs that urea synthesis from ammonia is limited by endogenous ornithine and that ornithine can pharmacologically promote urea formation to a greater degree than any ammonia supply.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego  •  2010  |  View Paper
From these … conclude that ammonia , a direct substrate for urea synthesis, … control the concentrations of both ornithine and acetylglutamate in the liver, directly or indirectly, although perfused liver lacks some factors that keep … concentration of ornithine at the in vivo level and cause its increase in response to ammonia.
Advances in enzyme regulation  •  1980  |  View Paper
The data indicate an increased detoxification rate of ammonia by arginine and ornithine supplementation.
Toxins  •  2018  |  View Paper
We also observed that the combination of hyperammonemia with ornithine resulted in significant decreases of sulfhydryl levels, reduced glutathione (GSH) concentrations and the activities of catalase (CAT) and glutathione peroxidase (GPx), highlighting a synergistic effect of ornithine and ammonia.
Metabolic Brain Disease  •  2012  |  View Paper
The concentration of ornithine rather than that of carbamoyl phosphate or the activity of the enzymes involved, may represent a limiting factor controlling both the flux of ammonia in the urea cycle and the availability of mitochondrial carbamoyl phosphate for orotic acid synthesis.
European journal of biochemistry  •  1998  |  View Paper
It is concluded that in sheep hepatocytes both ornithine and propionate stimulate the utilization of ammonia for urea synthesis and these effects take place independently and occur by different mechanisms.
The International journal of biochemistry  •  1990  |  View Paper
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