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Last Updated: 3 years ago

Possible Interaction: Ammonia and Manganese





Research Papers that Mention the Interaction

More recently, synergistic actions of ammonia and manganese , a toxic metal that is normally eliminated via the hepatobiliary route and shown to accumulate in brain in liver failure, on the glutamatergic neurotransmitter system were described.
Metabolic Brain Disease  •  2015  |  View Paper
Unexpectedly, MN consistently exhibited greater increases in plasma ammonia compared with NN despite the relatively lower accumulation of IMP in skeletal muscle.
Journal of applied physiology  •  2001  |  View Paper
When cultures were treated separately with 5 mM ammonia and 100 μM manganese for 2 days, the uptake of L-arginine increased by 41% and 57%, respectively.
Neurochemical Research  •  2004  |  View Paper
In conclusion, ammonia plus manganese exert additive/synergetic effects on the induction free radicals, mitochondrial inner membrane depolarization and cellular integrity, which may contribute to the tissue injury associated with chronic forms of HE.
Neurochemical Research  •  2004  |  View Paper
It was found that co-exposure of the brain mitochondria to Mn and ammonia causes more evident mitochondrial impairment in comparison with Mn and/or ammonia alone.
Clinical and experimental hepatology  •  2019  |  View Paper
However, with the increase of ammonia concentration, the leaching efficiency of Mn decreases dramatically to 4% due to the formation of double salts.
Waste management  •  2018  |  View Paper
The damage of the structures and the change of the chemical states of manganese might have a negative effect on the ammonia removal.
Journal of environmental sciences  •  2015  |  View Paper
In combination with broken-symmetry density functional theory, our results show that (i) … [Umena Y, et al. (2011) Nature 473(7345):55–60]}; (ii) ammonia … outer manganese (MnA4-W1); and (iii) as W1 is trans to O5, ammonia … resonance and to a small change in the water exchange rates.
Proceedings of the National Academy of Sciences  •  2013  |  View Paper
Ammonia and manganese act synergistically to activate mitochondrial benzodiazepine receptors leading to increased production of neuroactive steroids, many of which (allopregnanolone, THDOC) have potent neuroinhibitory properties resulting from activation of a neuromodulatory site on the GABA‐A receptor (“increased GABAergic tone”).
Hepatology research : the official journal of the Japan Society of Hepatology  •  2008  |  View Paper