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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Ammonia and Leucine

drug:

Ammonia

supplement:

Leucine

Research Papers that Mention the Interaction

The plasma concentrations of valine, leucine , isoleucine, phenylalanine, tyrosine, and methionine decreased after the ammonia load, whereas no changes were found in the plasma concentrations of glucagon and insulin.
Scandinavian journal of gastroenterology  •  1990  |  View Paper
260, 14683-14688] can be ascribed to inhibition of urea synthesis by leucine which results in accumulation of glutamate and of ammonia , the essential activator of glutaminase.
European journal of biochemistry  •  1990  |  View Paper
Alanine, leucine , and glutamine significantly (P less than 0.01) increased ammonia release into mesenteric venous blood by 37, 42, and 106%, respectively, whereas threonine, serine, and glycine had no effect.
The American journal of physiology  •  1988  |  View Paper
Acid proteases capable of hydrolyzing alpha-N-benzoyl-D,L-arginine-beta-naphthylamine (cathepsins B1, H, and L ) were also inhibited in situ by ammonia and cyanate.
Proceedings of the National Academy of Sciences of the United States of America  •  1981  |  View Paper