Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Ammonia and Histidine

drug:

Ammonia

supplement:

Histidine

Research Papers that Mention the Interaction

The data presented in the review show that HIS administration may increase ammonia and affect the level of several amino acids.
Physiological research  •  2020  |  View Paper
Using the osmotic shock method, the measured ammonia concentrations at 49 and 90 mg/dL showed greater than 10% change at HIs of 27.6 and 116.5, respectively.
Using the shearing method, the measured ammonia at 58 and 100 mg/dL had greater than 10% change at HIs of 219.7 and 814.2, respectively.
Archives of pathology & laboratory medicine  •  2012  |  View Paper
We conclude that HIS supplementation increases ammonia production , alanine and glutamine synthesis in muscles, affects turnover of proteins and HIS-containing peptides, and increases requirements for glycine and methionine.
Physiological research  •  2019  |  View Paper
L-histidine , an inhibitor of mitochondrial glutamine transport, was recently shown to mitigate OS, mPT, and cell swelling in cultured astrocytes treated with ammonia.
The American journal of pathology  •  2010  |  View Paper
Ammonia caused large stimulatory effects in incorporation of (14)C into glutamine (a factor of 21), aspartate, asparagine, valine, alanine, arginine, and histidine.
Plant physiology  •  1981  |  View Paper