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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Ammonia and Glutathione

drug:

Ammonia

supplement:

Glutathione

Research Papers that Mention the Interaction

In addition, ammonia induced increased reactive oxygen species (ROS) production and decreased GSH intracellular content, the main antioxidant in CNS.
Neurotoxicology  •  2015  |  View Paper
Simultaneously, ammonia facilitates the antioxidant response of the brain, by activating astrocytic transport and export of glutathione , in this way increasing the availability of precursors of neuronal glutathione synthesis.
Neurochemistry International  •  2013  |  View Paper
Ammonia in vitro stimulates GSH synthesis in cultured astrocytes, which may compensate for increased GSH consumption (decreased GSH/GSSG ratio) in neurons.
Metabolic brain disease  •  2005  |  View Paper
Ammonia decreased GSH levels and increased cytokine release and NFκB transcriptional activation.
Toxicology in vitro : an international journal published in association with BIBRA  •  2015  |  View Paper
Ammonia increased S100B secretion and decreased glutamate uptake, GS activity and glutathione (GSH) content.
Toxicology in vitro : an international journal published in association with BIBRA  •  2013  |  View Paper
A linear relationship was observed between ammonia concentration and the increase in GSH levels.
GSH content in the medium increased in a dose- and time-dependent manner in the presence of ammonia.
Neurochemistry International  •  2000  |  View Paper
Exposure to ammonia (NH4OH) for 48 h resulted in greater than 50% depletion of the hepatic glutathione pool in Channa punctatus (Bloch).
It is concluded that ammonia stress in a freshwater air-breathing teleost is counteracted by the glutathione system of detoxication of xenobiotics and resynthesis of glutathione is induced by short-term exposure to ammonia followed by transfer to ammonia-free water.
Toxicology letters  •  1983  |  View Paper