Possible Interaction: Ammonia and Glucose

“The exercise-induced increases in plasma ammonia , inosine, and hypoxanthine were much larger with glucose than with saline infusion in the patients.”

“ Ammonia also modulates BBB transport of the cationic amino acids: the nitric oxide precursor, arginine, and ornithine, which is an ammonia trap, and affects the transport of energy metabolites glucose and creatine.”

“ Ammonia caused a 60% decrease in the CHO cell yield from glucose , while N417 cells were barely affected, suggesting that increased resistance to ammonia by N417 cells is a global rather than glycosylation‐specific phenomenon.”

“Addition of albumin caused a marked increase in the production of ammonia, and addition of glucose increased bacterial assimilation of ammonia considerably.”

“Furthermore, the smaller the glucose increment , the earlier the ammonia rise.”

“However, a complicating factor in the diabetic is the elevated glucose concentration in … effects of urea by inhibiting ammonia formation and reducing the pH. Ammonia at alkaline pH …: 745, 1973) and glucose could reduce both by diverting urea metabolism in the … and KLEINBERG, Arch Oral Biol 16:759, 1971).”

“The addition of both glucose and urea stimulated the production of ammonia beyond the amount produced when urea alone was added.”

“The addition of glucose (2.5 per cent final concentration) to the incubating mixture inhibited ammonia production.”

“They showed further that ammonia inhibited the formation of acids in incubating mixtures of saliva and glucose and that urea in combination with the phosphate produced even more striking results.”

“Of the plasma components, various factors, such as serum total protein, albumin, glucose , glutamic-oxalacetic transaminase, and glutamic-pyruvic transaminase, were significantly altered in response to ammonia exposure.”

“Acute exposure to ammonia increased the enzyme profile of transaminases, glucose and urea.”