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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ammonia
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“Accumulation of ammonia induces a glutamate neurotoxicity leading to an increased tone of the γ-aminobutyric acid A (GABA-A) receptor system in the brain which results in HE.”
Management of Hepatic Encephalopathy: Role of Rifaximin“In addition, ammonia has been shown to inhibit astrocytic uptake of GABA by 30%–50%, an effect which would increase the synaptic availability of GABA at GABA(A) receptors.”
“Chronic exposure to ammonia is thought to inhibit astro cytic uptake of γ-aminobutyric acid —hence, perhaps, the appar ent reversal of coma by fl umazenil— and to increase neuro steroid synthesis, which contributes to encephalopathy.”
“ Ammonia also enhanced GABA release after 4-day treatment, although such release was initially inhibited.”
“These effects of ammonia (inhibition of GABA uptake and enhanced GABA release) may elevate extracellular levels of GABA and contribute to a dysfunction of GABAergic neurotransmission in HE and other hyperammonemic states.”
Effect of ammonia on GABA uptake and release in cultured astrocytes“ Ammonia inhibited the release of GABA and D-ASP.”
“Picrotoxin, bicuculline, ammonia and furosemide reversibly blocked the inhibition induced with GABA.”
“Combinations of 5 mM ammonia and 5 mM glutamic acid or 5 mM ammonia and 5 mM glutamine as nitrogen source, lead to a 4–5 fold reduction of the maximum activity measurable on 5 mM γ-aminobutyric acid.”
The control of glutamine synthetase level in Lemna minor L.“Plasma PA, but not plasma GABA , was closely correlated with plasma ammonia concentration in each group.”
“The production of labeled gamma-aminobutyric acid was virtually stopped by ammonia.”
“Substitution of ammonia with GABA , glutamate, or aspartate greatly reduces the effect of glucose on the synthesis of the GABA utilization enzymes.”
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