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Last Updated: 2 years ago

Possible Interaction: Ammonia and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

Accumulation of ammonia induces a glutamate neurotoxicity leading to an increased tone of the γ-aminobutyric acid A (GABA-A) receptor system in the brain which results in HE.
Chemotherapy  •  2005  |  View Paper
In addition, ammonia has been shown to inhibit astrocytic uptake of GABA by 30%–50%, an effect which would increase the synaptic availability of GABA at GABA(A) receptors.
Metabolic Brain Disease  •  2004  |  View Paper
Chronic exposure to ammonia is thought to inhibit astro cytic uptake of γ-aminobutyric acid —hence, perhaps, the appar ent reversal of coma by fl umazenil— and to increase neuro steroid synthesis, which contributes to encephalopathy.
The Lancet  •  2008  |  View Paper
Ammonia also enhanced GABA release after 4-day treatment, although such release was initially inhibited.
These effects of ammonia (inhibition of GABA uptake and enhanced GABA release) may elevate extracellular levels of GABA and contribute to a dysfunction of GABAergic neurotransmission in HE and other hyperammonemic states.
Neurochemistry International  •  2000  |  View Paper
Ammonia inhibited the release of GABA and D-ASP.
Brain Research  •  1994  |  View Paper
Picrotoxin, bicuculline, ammonia and furosemide reversibly blocked the inhibition induced with GABA.
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova  •  1985  |  View Paper
Combinations of 5 mM ammonia and 5 mM glutamic acid or 5 mM ammonia and 5 mM glutamine as nitrogen source, lead to a 4–5 fold reduction of the maximum activity measurable on 5 mM γ-aminobutyric acid.
Planta  •  2004  |  View Paper
Plasma PA, but not plasma GABA , was closely correlated with plasma ammonia concentration in each group.
Hepatology research : the official journal of the Japan Society of Hepatology  •  2000  |  View Paper
The production of labeled gamma-aminobutyric acid was virtually stopped by ammonia.
Plant physiology  •  1981  |  View Paper
Substitution of ammonia with GABA , glutamate, or aspartate greatly reduces the effect of glucose on the synthesis of the GABA utilization enzymes.
Journal of bacteriology  •  1972  |  View Paper