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Last Updated: 2 years ago

Possible Interaction: Ammonia and Creatine

drug:

Ammonia

supplement:

Creatine

Research Papers that Mention the Interaction

The results demonstrate that Cr ingestion can increase whole body exercise performance during the initial two, but not a third, successive bout of maximal exercise lasting 30 s. The lower accumulation of plasma ammonia under these conditions suggests this response is achieved by an effect on muscle ATP turnover.
European Journal of Applied Physiology and Occupational Physiology  •  2004  |  View Paper
Plasma ammonia accumulation was lower during and after exercise after creatine ingestion.
Clinical science  •  1993  |  View Paper
Ammonia also modulates BBB transport of the cationic amino acids: the nitric oxide precursor, arginine, and ornithine, which is an ammonia trap, and affects the transport of energy metabolites glucose and creatine.
Neurotoxicity Research  •  2011  |  View Paper
In particular, we could show that ammonia exposure generates a secondary deficiency in creatine in brain cells, by altering the brain expression and activity of the genes allowing creatine synthesis (AGAT and GAMT) and transport (SLC6A8).
We could also show that creatine co-treatment under ammonia exposure can protect developing brain cells from some of the deleterious effects of ammonia, in particular axonal growth impairment.
Molecular genetics and metabolism  •  2010  |  View Paper
Creatine was identified as a major source of interference with the direct phenol/hypochlorite colorimetric determination of ammonia in nitrogenase reaction mixtures.
Analytical biochemistry  •  1992  |  View Paper