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Last Updated: 3 years ago

Possible Interaction: Ammonia and Carnitine





Research Papers that Mention the Interaction

In the treated group of epileptics, TC and FC were negatively associated with ammonia (r=-0.896, p<0.0001; r=-0.935, p<0.0001).
Epilepsy Research  •  2009  |  View Paper
1 In animals and in cultured neurons, l‐carnitine and acetyl‐l‐carnitine (ALCAR) have been shown to counteract some of the toxic effects of ammonia.
Clinical and experimental pharmacology & physiology  •  2006  |  View Paper
Administration of carnitine prevents acute ammonia toxicity and enhances the efficacy of ammonia elimination as urea and glutamine.
In addition the cytotoxic effects of ammonia , possibly arising from lipid peroxidation, are ameliorated by carnitine.
Advances in experimental medicine and biology  •  1990  |  View Paper
Compounds that prevent ammonia toxicity in mice (e.g. carnitine ) also prevent Glu toxicity in cultured neurons.
Neurotoxicology  •  1998  |  View Paper
L‐carnitine administration prevents the neurological symptoms of acute ammonia toxicity.
Treatment with L‐carnitine reduced CSF ammonia at both precoma and coma stages; the time‐course of this protective effect paralleled blood and CSF L‐carnitine accumulation.
Hepatology  •  1997  |  View Paper
Carnitine prevents acute ammonia toxicity in animals.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
Moreover, the results suggest … protective effects of carnitine against the … of ammonia are systemic, that the action of acetyl-L-carnitine may differ from that of L- or D-carnitine, and … the "classical" function of carnitine is not the sole mechanism underlying the suppression of the neurotoxicity of ammonia.
Biochemical pharmacology  •  1993  |  View Paper