Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Ammonia and Carnitine





Research Papers that Mention the Interaction

In the treated group of epileptics, TC and FC were negatively associated with ammonia (r=-0.896, p<0.0001; r=-0.935, p<0.0001).
Epilepsy Research  •  2009  |  View Paper
Administration of carnitine prevents acute ammonia toxicity and enhances the efficacy of ammonia elimination as urea and glutamine.
In addition the cytotoxic effects of ammonia , possibly arising from lipid peroxidation, are ameliorated by carnitine.
Advances in experimental medicine and biology  •  1990  |  View Paper
In this paper, we report that in adult JVS mice, ammonia levels again increased after starvation for at least 24 hr and this effect was suppressed by carnitine treatment.
Metabolic Brain Disease  •  2002  |  View Paper
Compounds that prevent ammonia toxicity in mice (e.g. carnitine ) also prevent Glu toxicity in cultured neurons.
Neurotoxicology  •  1998  |  View Paper
Carnitine prevents acute ammonia toxicity in animals.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
Moreover, the results suggest … protective effects of carnitine against the … of ammonia are systemic, that the action of acetyl-L-carnitine may differ from that of L- or D-carnitine, and … the "classical" function of carnitine is not the sole mechanism underlying the suppression of the neurotoxicity of ammonia.
Biochemical pharmacology  •  1993  |  View Paper