Possible Interaction: Ammonia and Carnitine

“In the treated group of epileptics, TC and FC were negatively associated with ammonia (r=-0.896, p<0.0001; r=-0.935, p<0.0001).”

“1 In animals and in cultured neurons, l‐carnitine and acetyl‐l‐carnitine (ALCAR) have been shown to counteract some of the toxic effects of ammonia.”

“Administration of carnitine prevents acute ammonia toxicity and enhances the efficacy of ammonia elimination as urea and glutamine.”

“In addition the cytotoxic effects of ammonia , possibly arising from lipid peroxidation, are ameliorated by carnitine.”

“Compounds that prevent ammonia toxicity in mice (e.g. carnitine ) also prevent Glu toxicity in cultured neurons.”

“ L‐carnitine administration prevents the neurological symptoms of acute ammonia toxicity.”

“Treatment with L‐carnitine reduced CSF ammonia at both precoma and coma stages; the time‐course of this protective effect paralleled blood and CSF L‐carnitine accumulation.”

“ Carnitine prevents acute ammonia toxicity in animals.”

“Moreover, the results suggest … protective effects of carnitine against the … of ammonia are systemic, that the action of acetyl-L-carnitine may differ from that of L- or D-carnitine, and … the "classical" function of carnitine is not the sole mechanism underlying the suppression of the neurotoxicity of ammonia.”