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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Ammonia and Biotin

drug:

Ammonia

supplement:

Biotin

Research Papers that Mention the Interaction

In mice also, increases in blood and brain ammonia levels after ammonia loading were prevented by the administration of biotin.
Increases in blood ammonia levels in rats 15–30 min after ammonia loading were prevented by treatment with 0.2 ml/100 g BW of biotin or 0.04 ml/100g BW of arginineglutamate with statistical significance.
Journal of Gastroenterology  •  2006  |  View Paper
It suggests that biotin might decrease blood ammonia by facilitating the detoxification mechanism as follow: L-glutamate + NH3----L-glutamine.
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology  •  1989  |  View Paper
Feeding biotin increased net PDV release of ammonia.
Animal : an international journal of animal bioscience  •  2007  |  View Paper